“Catch and release” cascades: a resin- mediated three-component cascade approach to small molecules

نویسندگان

  • Ronald Grigg
  • Andrew Cook
چکیده

The application of a “catch and release” approach to palladium catalysed multi-component cascade reactions leads to diverse libraries of pharmacologically interesting small molecules in high yield and with excellent purity. © 2007 Elsevier Science. All rights reserved

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A one-pot, microwave-influenced synthesis of diverse small molecules by multicomponent reaction cascades.

Small molecule diversity can be achieved in a single synthetic operation from bifunctional substrates in the absence of additives and under the influence of microwaves with complete control of pathway selectivity. The preliminary Ugi four-component coupling products give rise to three structurally distinct scaffolds that are dependent on solvent effects and sterics. 2,5-Diketopiperazines (Type ...

متن کامل

Copper-mediated three-component synthesis of 3-cyanoimidazo[1,2-a]pyridines.

A copper-mediated three-component approach towards the synthesis of 3-cyanoimidazo[1,2-a]pyridines from 2-aminopyridines, acetophenones and benzyl cyanide was developed. This cascade reaction proceeds through a copper-mediated oxidative release of cyanide from benzyl cyanide, a copper-mediated Ortoleva-King reaction, and a copper-catalyzed cyanation.

متن کامل

P3: Mechanisms of TrkB-Mediated Hippocampal Long-Term Potentiation in Learning and Memory

Long-term potentiation (LTP) is a process that certain types of synaptic stimulation lead to a long-lasting enhancement in the strength of synaptic transmission. Studies in recent years indicate the importance of molecular pathways in the development of memory and learning. Tropomyosin receptor kinase B (TrkB) is a member of the neurotrophin receptor tyrosine kinase family, that its ligand is b...

متن کامل

A 2-D Numerical Investigation on the Modal Characteristics of Rotating-Stall with a Variable-Cascade- Length Approach in an Axial Compressor

The Rotating-Stall (RS) through a rotor-cascade of an axial compressor were numerically investigated with an unsteady two-dimensional finite-volume density based computer code. To validate the computer code, a test case was prepared and the good agreement of the compared results has given the adequate assurance of the code. The RS was incepted with a 40% reduction in flow coefficient and a 0.4%...

متن کامل

Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling.

The features of three distinct protein phosphorylation cascades in mammalian cells are becoming clear. These signalling pathways link receptor-mediated events at the cell surface or intracellular perturbations such as DNA damage to changes in cytoskeletal structure, vesicle transport and altered transcription factor activity. The best known pathway, the Ras-->Raf-->MEK-->ERK cascade [where ERK ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016